Mesenchymal stem cells isolated from human umbilical cord (hMSCs) are modified for the treatment of Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig’s disease).
The present invention provides decellularized cartilage (DCC) fragments or powder as a raw material component to be utilized for scaffolds and provides a microenvironment similar to that of native cartilage tissue. The DCC powder provides a platform technology upon which many cartilage, or even bone, tissue engineering scaffolds could be based.
A device for rapid dialysis of microliter volume liquid samples useful in laboratory-scale dialysis operations.
Novel ligands designed to activate mu opioid receptors and provide analgesic effects without opioid-related side effects, providing specific insight into the cellular impact of opioid receptor-based activation as related to pain medications. These ligands could be used as a tool to negate drug tolerance and dependence as well as other adverse side effects.
The invention relates to protecting against Salmonella-type pathogens and more particularly, compositions and methods for immunizing against infection by typhoidal and non-typhoidal Salmonella serovars.
This invention provides an improved method for producing a novel interfacing capillary device that is less costly and more durable than existing sheathless devices. This simplified production method does not require sample dilution, etching, or precision hand tools, and is automated and reproducible.
Regenerating and repairing individual organs and tissues for a single patient requires mass quantities of the patient’s own adult stem cells. Mass production of adult stem cells for therapeutic applications is highly limited due to the fact that adult stem cells have a limited shelf life when isolated from primary tissues of humans and animals. The act of removing adult stem cells from their original environment is traumatic and has the potential to induce changes or negative effects. Furthermore, the ability to grow adult stem cells in environments that mimic the original host tissue are limited. Adult stem cells lose “stemness” characteristics and the ability to divide and differentiate as adult stem cells are maintained and dissociated (passaged) from growth substrates, as is current practice.
Use of a genetic dereplication strategy eliminates major known SM biosynthetic pathways in Aspergillus nidulans, reducing the complexity of SM profiles and activating an abundance of silent SM gene clusters to enable identification of a new pool of fungal products for drug discovery.
The small molecules in this work represent a novel composition of matter that can be used as either Kappa Opioid Receptor (KOR) agonists or antagonists. Further some of the compounds have been shown to weak agonists making them ideal to explore for the use of addiction.