Category: biomarkers

This invention provides an improved method for producing a novel interfacing capillary device that is less costly and more durable than existing sheathless devices.  This simplified production method does not require sample dilution, etching, or precision hand tools, and is automated and reproducible.  

Hearing loss, tinnitus, and vertigo result from the damage of mechanosensory hair cells (HCs) located in sensory epithelium of the cochlea and vestibular organs of the inner ear. HCs do not regenerate. Currently, hearing aids and cochlear implants are the only treatments to address hearing loss, and both options provide mild relief. The challenge in developing new therapies and screening ototoxic agents is that the cochlear and vestibular sensory epithelium are isolated deep in the inner ear. Invasive measures are required to access the sensory epithelium. KU researchers have endeavored to create both cochlear and vestibular sensory epithelium outside of the body. They are developing a model platform where the cochlear and vestibular sensory epithelium can be grown outside of the body for testing and developing new diagnostics, screening ototoxic agents, and evaluating new therapies. No such model currently exists. Thus, this technology has the potential to take a leap forward in the advancement of medicine for hearing disorders.
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The invention offers novel composition of matter to be used in treatment of a number of hormone responsive cancers.

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A novel method of inducing adult-derived stem cell proliferation in tissue from adult animals. Harvested embryonic, pluripotent or more differentiated stem cells may be used in cell therapy, tissue engineering, or other medical, veterinary, and industrial applications.

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This invention uses microRNA biomarkers to detect or diagnose Barrett's esophagus, detect dysplasia in Barrett's esophagus, and detect early onset of esophageal cancer.

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