A novel method for detecting and monitoring the reactive nitrogen species peroxynitrite in normal physiology and human pathology. The invention offers significant advantages over traditional methods for detecting and monitoring the cellular production of peroxynitrite by overcoming limitations of other sensors. This is important because current methods are less sensitive and less robust, especially for studies of living cells such as its involvement in immunology. This invention may yield better information about the effects of peroxynitrite in a variety of diseases including infectious disease, cancer, neurodegeneration, and others.
The technology presents a novel structural modification of an existing first generation Grp94 selective inhibitor to generate a second generation Grp94-specific scaffold which has greater affinity and selectivity compared to existing inhibitors and prevents unfavorable binding of other Hsp90 isoforms.
Unique chemical derivatives invented by University of Kansas (KU) researchers that could be used to detect inhibitors of cellular efflux transporters and other agents.
Novel ligands designed to activate mu opioid receptors and provide analgesic effects without opioid-related side effects, providing specific insight into the cellular impact of opioid receptor-based activation as related to pain medications. These ligands could be used as a tool to negate drug tolerance and dependence as well as other adverse side effects.
This invention provides an improved method for producing a novel interfacing capillary device that is less costly and more durable than existing sheathless devices. This simplified production method does not require sample dilution, etching, or precision hand tools, and is automated and reproducible.
Broad based label-free systems identify protein stabilizers at physiological or near physiological conditions that specifically inhibit Bacterial Toxin or Viral entry into cells.
PEPCK is an enzyme critical in the process of gluconeogenesis whose inhibition could be used to treat hyperglycemia and diabetes.
The present invention employs a novel use of logic and data analysis tools to improve the efficiency of drug discovery.
The current invention is a novel class of compounds that function as KOR antagonists. Because KOR activation has been linked to depression and anxiety related disorders, this novel class of compounds may be used in the development of therapies to treat these mental disorders