A novel method for detecting and monitoring the reactive nitrogen species peroxynitrite in normal physiology and human pathology. The invention offers significant advantages over traditional methods for detecting and monitoring the cellular production of peroxynitrite by overcoming limitations of other sensors. This is important because current methods are less sensitive and less robust, especially for studies of living cells such as its involvement in immunology. This invention may yield better information about the effects of peroxynitrite in a variety of diseases including infectious disease, cancer, neurodegeneration, and others.
A novel method for measuring olfactory dysfunction. The method offers significant advantages over the traditional method for measuring olfactory dysfunction such as UPSIT and overcomes many of the limitations and concerns with its affordable, accessible, and user-friendly method to measure olfactory dysfunction using essential oils in alterable concentrations.
Mesenchymal stem cells isolated from human umbilical cord (hMSCs) are modified for the treatment of Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig’s disease).
The technology presents a novel structural modification of an existing first generation Grp94 selective inhibitor to generate a second generation Grp94-specific scaffold which has greater affinity and selectivity compared to existing inhibitors and prevents unfavorable binding of other Hsp90 isoforms.
Unique chemical derivatives invented by University of Kansas (KU) researchers that could be used to detect inhibitors of cellular efflux transporters and other agents.
The present invention provides decellularized cartilage (DCC) fragments or powder as a raw material component to be utilized for scaffolds and provides a microenvironment similar to that of native cartilage tissue. The DCC powder provides a platform technology upon which many cartilage, or even bone, tissue engineering scaffolds could be based.
Novel ligands designed to activate mu opioid receptors and provide analgesic effects without opioid-related side effects, providing specific insight into the cellular impact of opioid receptor-based activation as related to pain medications. These ligands could be used as a tool to negate drug tolerance and dependence as well as other adverse side effects.
The invention relates to protecting against Salmonella-type pathogens and more particularly, compositions and methods for immunizing against infection by typhoidal and non-typhoidal Salmonella serovars.
This invention provides an improved method for producing a novel interfacing capillary device that is less costly and more durable than existing sheathless devices. This simplified production method does not require sample dilution, etching, or precision hand tools, and is automated and reproducible.
Small camera/collection device that collects samples all along the surface of the esophagus, increasing disease detection rate.