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An unprecedented rational approach to dysregulate bacterial iron homeostasis by small molecule probes designed to inhibit the mobilization of iron from BfrB (bacterioferritin), the iron storage protein in Pseudomonas aeruginosa.
KU researchers have developed a computer-based image overlapping approach for detecting structural defects in metallic structures.
A KU researcher has developed a superomniphobic (superhydrophobic and superoleophobic) coating material that is self-healing when damaged and retains its super-repellency.
A novel method for evaluating cerebrovascular health in a patient in response to exercise. The method offers significant advantages over the traditional methods for monitoring cerebrovascular health and overcomes many of the limitations and concerns with understanding the fundamental mechanisms controlling cerebrovascular function. This is important because understanding the middle cerebral artery dynamic response during different exercise intensities is vital for understanding brain health, overall cerebrovascular function and designing and evaluating exercise strategies for maximizing therapeutic potential.
A novel method for detecting and monitoring the reactive nitrogen species peroxynitrite in normal physiology and human pathology. The invention offers significant advantages over traditional methods for detecting and monitoring the cellular production of peroxynitrite by overcoming limitations of other sensors. This is important because current methods are less sensitive and less robust, especially for studies of living cells such as its involvement in immunology. This invention may yield better information about the effects of peroxynitrite in a variety of diseases including infectious disease, cancer, neurodegeneration, and others.
This invention is a method for isolating tumor-specific T cell receptors (TCRs) in a format that allows for rapid discovery, amplification, and return to a patient for therapeutic use.
This invention is a method for improving electron microscopy image quality of a sample by increasing the electrical conductivity of the sample. The increased conductivity of the sample counteracts detrimental surface charging typically caused by electron microscopes. The method also increases the stability of the sample for higher quality serial sectioning.
A novel method for measuring olfactory dysfunction. The method offers significant advantages over the traditional method for measuring olfactory dysfunction such as UPSIT and overcomes many of the limitations and concerns with its affordable, accessible, and user-friendly method to measure olfactory dysfunction using essential oils in alterable concentrations.
A system for improving the performance of existing air conditioning and refrigeration approaches has been developed.
A novel computer vision-based approach for fatigue crack detection using a video stream was developed. The technology offers significant advantages over traditional inspection and fixed sensor-based methods and overcomes many of the limitations and concerns with static image and image processing based techniques.